Original Research Report
Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum
Do Hyun Lee Nutrex Technology R&D Center, Seoul, South Korea, In Young Oh Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea, Kyo Tan Koo Nutrex Technology R&D Center, Seoul, South Korea, Jang Mi Suk P&K Skin Research Center, Seoul, South Korea, Sang Wook Jung P&K Skin Research Center, Seoul, South Korea, Jin Oh Park Daebong LS, Incheon, South Korea, Beom Joon Kim Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South KoreaCorrespondencebeomjoon@unitel.co.kr
& Yoo Mi Choi Pacificpharma, Cosmeceutical Team, Seoul, South Korea show all
Pages 20-23 | Received 02 Jan 2014, Accepted 10 Sep 2014, Accepted author version posted online: 26 Sep 2014, Published online: 27 Oct 2014
Background: Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon.
Objective: We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet).
Materials and methods: In total, 23 Korean women (age range: 39–59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed.
Results: Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis.
Conclusion: Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles.
Key Words:: human growth factor, hyaluronic acid, wrinkle